Aniline → Benzenesulfonamide, 4-methyl-N-phenyl-
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8]1([CH3:18])[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:9]=1>N1C=CC=CC=1>[CH3:18][C:8]1[CH:13]=[CH:12][C:11]([S:14]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)(=[O:16])=[O:15])=[CH:10][CH:9]=1참가 물질
4
반응 조건
- 온도
- 5 °C
실험 절차
Dissolve aniline (930 mg, 10 mmol) in anhydrous pyridine (25 mL) and cool to 5° C. Add, by dropwise addition, p-toluenesulfonyl chloride (2.1 g, 11 mmol) and stir overnight. Partition between water and ethyl acetate and separate the organic phase. Wash the organic phase with cold 1N hydrochloric acid, saturated sodium hydrogen carbonate and brine. Dry (MgSO4) and evaporate the solvent in vacuo to give the title compound.
후처리
- customPartition between water and ethyl acetate
- customseparate the organic phase
- washWash the organic phase with cold 1N hydrochloric acid, saturated sodium hydrogen carbonate and brine
- dry with materialDry (MgSO4)
- customevaporate the solvent in vacuo
출처 및 근거
- ORD 기록
- ord-17afee4eb84643fa9f4983b8a056dfdb
- 출처 데이터셋
- uspto-grants-1993_06
- 특허 번호
- US05217964
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