Aniline → Benzenesulfonamide, 4-methyl-N-phenyl-

HRID 1587544

반응식

HRID 1587544 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8]1([CH3:18])[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:9]=1>N1C=CC=CC=1>[CH3:18][C:8]1[CH:13]=[CH:12][C:11]([S:14]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)(=[O:16])=[O:15])=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 6115AnilineHCID 73974-Toluenesulfonyl chloride

생성물 1

HCID 2456Benzenesulfonamide, 4-methyl-N-phenyl-

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
5 °C

실험 절차

Dissolve aniline (930 mg, 10 mmol) in anhydrous pyridine (25 mL) and cool to 5° C. Add, by dropwise addition, p-toluenesulfonyl chloride (2.1 g, 11 mmol) and stir overnight. Partition between water and ethyl acetate and separate the organic phase. Wash the organic phase with cold 1N hydrochloric acid, saturated sodium hydrogen carbonate and brine. Dry (MgSO4) and evaporate the solvent in vacuo to give the title compound.

후처리

  1. customPartition between water and ethyl acetate
  2. customseparate the organic phase
  3. washWash the organic phase with cold 1N hydrochloric acid, saturated sodium hydrogen carbonate and brine
  4. dry with materialDry (MgSO4)
  5. customevaporate the solvent in vacuo

출처 및 근거

ORD 기록
ord-17afee4eb84643fa9f4983b8a056dfdb
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05217964

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