Dimethyl Sulfoxide → 2-(2-Trifluoromethyl-thiazol-4-yl)glyoxal

HRID 1587888노트

반응식

HRID 1587888 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:11])[CH2:9]Br)[N:7]=1.CS(C)=[O:16]>>[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:11])[CH:9]=[O:16])[N:7]=1

참가 물질

3

반응물 2

HCID 679Dimethyl SulfoxideHCID 10978660HCID 10978660, 화합물

생성물 1

HCID 199742732-(2-Trifluoromethyl-thiazol-4-yl)glyoxal

실험 절차

3 g (0.011 mol) of 2-Trifluoromethyl-4-bromoacetyl-thiazole are dissolved in 30 ml of dimethyl sulphoxide and the solution is maintained at room temperature for 70 hours. It is then poured onto 100 g of ice, and the mixture is extracted several times with ether, the organic phase is dried over sodium sulphate and concentrated, and the residue is purified on a silica gel column using toluene/ethyl acetate=7/3 as eluant.

후처리

  1. extractionthe mixture is extracted several times with ether
  2. dry with materialthe organic phase is dried over sodium sulphate
  3. concentrationconcentrated
  4. customthe residue is purified on a silica gel column

출처 및 근거

ORD 기록
ord-467ad6977e9d496daf962429dcd7adf6
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05219852

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