Hydrogen Bromide → 2-Trifluoromethyl-5-methyl-4-bromoacetyl-thiazole
반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][C:5]([CH3:11])=[C:6]([C:8](=[O:10])[CH3:9])[N:7]=1.[BrH:14].BrBr>C(O)(=O)C>[F:13][C:2]([F:1])([F:12])[C:3]1[S:4][C:5]([CH3:11])=[C:6]([C:8](=[O:10])[CH2:9][Br:14])[N:7]=1참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
3 g (0.0144 mol) of 2-Trifluoromethyl-5-methyl-4-acetyl-thiazole are dissolved in 30 ml of glacial acetic acid, and 2.1 ml of a 33% strength solution of hydrogen bromide in glacial acetic acid are added. The mixture is heated to 80° C. and, over the course of 30 minutes, a solution of 2.3 g (0.0144 mol) of bromine in 15 ml of glacial acetic acid is added. After a further 20 minutes, the glacial acetic acid is removed. The residue which remains is a dark oil which is reacted further as the crude product.
후처리
- customthe glacial acetic acid is removed
- customis reacted further as the crude product
출처 및 근거
- ORD 기록
- ord-d869932f2f404d21bb54e49e1255dd2f
- 출처 데이터셋
- uspto-grants-1993_06
- 특허 번호
- US05219852
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