Sodium Hydroxide → N-[2-(4-Carboxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

HRID 1587909노트

반응식

HRID 1587909 반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH:14][CH2:15][CH:16]([OH:26])[C:17]2[N:18]=[C:19]([C:22]([F:25])([F:24])[F:23])[S:20][CH:21]=2)[CH3:13])=[CH:7][CH:6]=1)([O:3]C)=[O:2].[OH-].[Na+]>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH:14][CH2:15][CH:16]([OH:26])[C:17]2[N:18]=[C:19]([C:22]([F:24])([F:23])[F:25])[S:20][CH:21]=2)[CH3:13])=[CH:7][CH:6]=1)([OH:3])=[O:2]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 19974173N-[2-(4-Carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

생성물 1

HCID 14076229N-[2-(4-Carboxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

실험 절차

Prepared analogously to Example 2 by reaction of N-[2-(4-carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine with 1N sodium hydroxide solution. After neutralisation with hydrochloric acid, the mixture is evaporated to dryness and the residue is treated with a mixture of ethyl acetate/ethanol=6:1. The extract is evaporated to dryness and the residue is triturated with 5 ml of water. The water is decanted off and the remaining residue is taken up in methanol, the solution is evaporated to dryness, and the residue is triturated with ether and filtered off with suction.

후처리

  1. customAfter neutralisation with hydrochloric acid, the mixture is evaporated to dryness
  2. additionthe residue is treated with a mixture of ethyl acetate/ethanol=6:1
  3. customThe extract is evaporated to dryness
  4. customthe residue is triturated with 5 ml of water
  5. customThe water is decanted off
  6. customthe solution is evaporated to dryness
  7. customthe residue is triturated with ether
  8. filtrationfiltered off with suction

출처 및 근거

ORD 기록
ord-b024158f5008490da4f41500da016f97
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05219852

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