Triethoxysilane → 1H-Pyrrole, 1-(phenylmethyl)-

HRID 1588019

반응식

HRID 1588019 반응식
[CH2:1]([N:8]1[C:12](=O)[CH2:11][CH2:10][C:9]1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O[SiH](OCC)OCC)C>C1C=CC=CC=1.CC(C)[O-].[Ti+4].CC(C)[O-].CC(C)[O-].CC(C)[O-]>[CH2:1]([N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 13830TriethoxysilaneHCID 952411-(Phenylmethyl)-2,5-pyrrolidinedione

생성물 1

HCID 749221H-Pyrrole, 1-(phenylmethyl)-수율 92.2%

시약·촉매·용매 2

HCID 11026Titanium isopropoxide촉매HCID 241Benzene용매

반응 조건

온도
60 °C

실험 절차

N-benzylsuccinimide (0.38 g, 2.0 mmol), triethoxysilane (1.85 mL, 10 mmol), and titanium (IV) isopropoxide (0.06 mL, 0.2 mmol) were dissolved in C6H6 (4.0 mL) and the mixture was heated to 60 ° C. for 16 hours. The solvent was removed in vacuo and the reaction mixture was poured into a mixture of 1 M NaOH (10 mL) and THF (10 mL). This mixture was stirred for 1 hour, poured into ethyl ether (75 mL), and washed with 1 M NaOH (5×50 mL). The ether layer was dried over MgSO4, filtered, and the solvent was removed in vacuo to produce 0.29 g (91% yield) of N-benzylpyrrole as a yellow oil.

후처리

  1. customThe solvent was removed in vacuo
  2. additionthe reaction mixture was poured into a mixture of 1 M NaOH (10 mL) and THF (10 mL)
  3. additionpoured into ethyl ether (75 mL)
  4. washwashed with 1 M NaOH (5×50 mL)
  5. dry with materialThe ether layer was dried over MgSO4
  6. filtrationfiltered
  7. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-58f0e60f495f45b2ace2c787867927c7
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05220020

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