Acetic Anhydride → 3-Nitro-N-(acetyl)benzenesulfonamide

HRID 1588038노트

반응식

HRID 1588038 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[C:14](OC(=O)C)(=[O:16])[CH3:15]>O1CCCC1>[N+:1]([C:4]1[CH:5]=[C:6]([S:10]([NH:13][C:14](=[O:16])[CH3:15])(=[O:11])=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 67138Benzenesulfonamide, 3-nitro-

생성물 1

HCID 189578003-Nitro-N-(acetyl)benzenesulfonamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 3-nitrobenzenesulfonamide (615 mg) in 10 ml of dry tetrahydrofuran was cooled to 0° C. and mixed with 0.34 ml of acetic anhydride and 166 mg of 4-N,N-dimethylaminopyridine. The reaction mixture was stirred for 30 minutes, quenched with 10% citric acid solution, and diluted with ethyl acetate. The reaction mixture was extracted with ethyl acetate. The organic extracts were washed with brine, dried, concentrated in vacuo to yield 946 mg of the title compound in pure form.

후처리

  1. customquenched with 10% citric acid solution
  2. additiondiluted with ethyl acetate
  3. extractionThe reaction mixture was extracted with ethyl acetate
  4. washThe organic extracts were washed with brine
  5. customdried
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-9387e865494f4e3ba1157d89058cb0af
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05220018

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