Hydrochloric Acid → 3-(2-Amino-4-thiazolyl)-L-alanine methyl ester dihydrochloride
반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C@@H:8]([C:10]([OH:12])=[O:11])[NH2:9])[N:6]=1.[ClH:13].[CH3:14]O>>[ClH:13].[ClH:13].[CH3:14][O:11][C:10](=[O:12])[C@H:8]([CH2:7][C:5]1[N:6]=[C:2]([NH2:1])[S:3][CH:4]=1)[NH2:9]참가 물질
4
반응 조건
- 온도
- 5 °C
실험 절차
3-(2-Amino-4-thiazolyl)-L-alanine containing methanol, 26.3 kg (76 mol) and 72 L of methanol are charged into a reactor and stirred at 5° C., followed by 16.9 kg of anhydrous hydrogen chloride gas and stirred at 25° C. for 5 hours. The solution is heated to reflux and then cooled to 5° C. and held for 1 hour. The product is filtered and dried under vacuum at 50° C. to give 17.7 kg of 3-(2-amino-4-thiazolyl)-L-alanine methyl ester dihydrochloride as an off-white solid, 99% pure by HPLC; IR (mineral oil): 3410 (sh), 1749 (sh), 1631 (sh), 1225 (m) cm-1.