Isobutyronitrile → N-(2-morpholinophenyl)isobutyramidine

HRID 1588594노트

반응식

HRID 1588594 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[C:14](#[N:18])[CH:15]([CH3:17])[CH3:16].[Cl-].[Al+3].[Cl-].[Cl-]>>[O:11]1[CH2:12][CH2:13][N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:14](=[NH:18])[CH:15]([CH3:17])[CH3:16])[CH2:9][CH2:10]1

참가 물질

4

반응물 3

HCID 6559IsobutyronitrileHCID 7357562-MorpholinoanilineHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 178449872N-(2-morpholinophenyl)isobutyramidine

실험 절차

A mixture of 4-(2-aminophenyl)morpholine (5.34 g), isobutyronitrile (6 g) and anhydrous aluminium chloride (12 g) was heated at 160°-170° C. for 6 hours to give N-(2-morpholinophenyl)isobutyramidine (m.p. 138° C.) which was recrystallised from a 1:1 mixture of ethylacetate and hexane.

후처리

  1. temperaturewas heated at 160°-170° C. for 6 hours

출처 및 근거

ORD 기록
ord-befa20bdae8b490b970f9ff55afb9737
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05223498

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