Triphenylphosphine → (4-Fluoro-3-phenoxyphenyl)methyltriphenylphosphonium chloride

HRID 1588891노트

반응식

HRID 1588891 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][Cl:9])=[CH:4][C:3]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[C:17]1([P:23]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>O1CCCC1>[Cl-:9].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][P+:23]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:4][C:3]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 135636494-(Chloromethyl)-1-fluoro-2-phenoxybenzene

생성물 1

HCID 19754846(4-Fluoro-3-phenoxyphenyl)methyltriphenylphosphonium chloride수율 60.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 11.8 grams (0.05 mole) of 4-fluoro-3-phenoxyphenylmethyl chloride (prepared in Example 2, Step B) and 13.1 grams (0.05 mole) of triphenylphosphine in 150 mL of dry tetrahydrofuran was stirred for about 60 hours. After this time the reaction mixture was concentrated under reduced pressure to a solid residue. The solid was stirred with diethyl ether and was collected by filtration, yielding 15 grams of (4-fluoro-3-phenoxyphenyl)methyltriphenylphosphonium chloride.

후처리

  1. concentrationAfter this time the reaction mixture was concentrated under reduced pressure to a solid residue
  2. filtrationwas collected by filtration

출처 및 근거

ORD 기록
ord-b9b22a9537e44d80ab852cb5ff771a19
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05223536

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