Hydrochloric Acid → 2-Piperazinecarboxylic acid,4-phenyl-1-(phenylmethyl)-

HRID 1588980노트

반응식

HRID 1588980 반응식
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:9]([C:20](N)=[O:21])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:23].[K+].Cl.O>C(O)CO>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:9]([C:20]([OH:21])=[O:23])[CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 109900971-Benzyl-4-phenyl-piperazine-2-carboxamide

생성물 1

HCID 149988012-Piperazinecarboxylic acid,4-phenyl-1-(phenylmethyl)-

시약·촉매·용매 1

HCID 174Ethylene Glycol용매

반응 조건

온도
150 °C

실험 절차

Suspend 4-phenyl-1-(phenylmethyl)-2-piperazinecarboxamide (14.5 g, 49 mmol) in ethylene glycol (400 mL) and add potassium hydroxide (27.5 g, 490 mmol). Heat this mixture to 150° C. for 18 h. After this time, remove the solvent in vacuo. Add 6M hydrochloric acid (81.5 mL, 0.49 mol) and water (300 mL) and filter the resultant solid to obtain the title compound.

후처리

  1. customAfter this time, remove the solvent in vacuo
  2. filtrationfilter the resultant solid

출처 및 근거

ORD 기록
ord-6a44282423354bc5be620a297419ab21
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05223623

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