2-Amino-4,6-dimethoxy-1,3,5-triazine → 1-(2-Biphenylylsulfonyl) 3-(4,6-dimethoxy-1,3,5-triazin-2-yl)thiourea

HRID 1589089

반응식

HRID 1589089 반응식
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([O:10][CH3:11])[N:3]=1.[C:12]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[S:24]([N:27]=[C:28]=[S:29])(=[O:26])=[O:25])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1(C)C=CC=CC=1>[C:18]1([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[S:24]([NH:27][C:28]([NH:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([O:10][CH3:11])[N:3]=1)=[S:29])(=[O:25])=[O:26]

참가 물질

4

반응물 2

HCID 278402-Amino-4,6-dimethoxy-1,3,5-triazineHCID 134220272-Phenylbenzenesulfonyl isothiocyanate

생성물 1

HCID 134220281-(2-Biphenylylsulfonyl) 3-(4,6-dimethoxy-1,3,5-triazin-2-yl)thiourea수율 81.2%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

15.6 g of 2-amino-4,6-dimethoxy-1,3,5-triazine were suspended in 300 ml of dry toluene, and 27.5 g of 2-phenylbenzenesulfonyl isothiocyanate were added. The mixture was heated under reflux for 8 hours. After cooling, the resulting precipitate was collected by filtration and recrystallized from ethanol to give 35 g of 1-(2-biphenylylsulfonyl) 3-(4,6-dimethoxy-1,3,5-triazin-2-yl)thiourea represented by the following formula: ##STR28##

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 8 hours
  3. temperatureAfter cooling
  4. filtrationthe resulting precipitate was collected by filtration
  5. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-525af155c139434cbe0271954b398de2
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04568381

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