Sodium Hydroxide → HCID 13588903, 화합물

HRID 1589168노트

반응식

HRID 1589168 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.Cl.Cl.[N:13]1([CH2:18][CH2:19][NH2:20])[CH:17]=[N:16][CH:15]=[N:14]1.[OH-].[Na+]>C(Cl)Cl>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:20][CH2:19][CH2:18][N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)=[O:7])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 14798Sodium Hydroxide2회HCID 685154-Bromobenzoyl chlorideHCID 202483172-(1H-1,2,4-triazol-1-yl)ethan-1-amine dihydrochloride

생성물 1

HCID 13588903HCID 13588903, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A mixture of about 2.2 g of 4-bromobenzoyl chloride, about 1.85 g of 1H-1,2,4-triazole-1-ethanamine dihydrochloride, about 30 ml of approximately 1N sodium hydroxide and about 75 ml of methylene chloride was stirred overnight, then about 5 ml of approximately 1N sodium hydroxide and about 75 ml of methylene chloride were added. The layers were separated and the organic layer was concentrated to remove the solvent. The crystalline residue was washed onto a filter with ether giving the desired product, mp 160°-162° C.

후처리

  1. customThe layers were separated
  2. concentrationthe organic layer was concentrated
  3. customto remove the solvent
  4. washThe crystalline residue was washed onto
  5. filtrationa filter with ether giving the desired product, mp 160°-162° C.

출처 및 근거

ORD 기록
ord-86262e30502a4fde9c5178cfcb9d3f25
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04568685

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