Sodium Hydroxide → 4-Bromo-N-[3-(4-phenyl-1H-imidazol-1-yl)propyl]benzamide

HRID 1589179노트

반응식

HRID 1589179 반응식
[C:1]1([C:7]2[N:8]=[CH:9][N:10]([CH2:12][CH2:13][CH2:14][NH2:15])[CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].[Br:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1>C(Cl)Cl>[Br:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:15][CH2:14][CH2:13][CH2:12][N:10]2[CH:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[N:8]=[CH:9]2)=[O:24])=[CH:21][CH:20]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 685154-Bromobenzoyl chlorideHCID 135889123-(4-Phenyl-1H-imidazol-1-yl)propan-1-amine

생성물 1

HCID 135889214-Bromo-N-[3-(4-phenyl-1H-imidazol-1-yl)propyl]benzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A mixture of 2.0 g. of 4-phenyl-1H-imidazole-1-propanamine, 50 ml. of methylenechloride and 10 ml. of 1N sodium hydroxide was stirred and 2.2 g. of 4-bromobenzoyl chloride was added. The mixture was stirred for eighteen hours, methylene chloride was added and the layers were separated. The organic layer was washed with water, dried over magnesium sulfate and concentrated. The residue was washed onto a filter with ether, giving the desired product, m.p. 132°-135° C.

후처리

  1. additionA mixture of 2.0 g
  2. customthe layers were separated
  3. washThe organic layer was washed with water
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated
  6. washThe residue was washed onto
  7. filtrationa filter with ether

출처 및 근거

ORD 기록
ord-14ba947b417f4cf19189d66d73aa7c44
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04568687

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