Benzyl Bromide → N-Benzyl-N-[3-(1H-imidazol-1-yl)propyl]benzamide

HRID 1589187노트

반응식

HRID 1589187 반응식
[N:1]1([CH2:6][CH2:7][CH2:8][NH:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[H-].[Na+].[CH2:20](Br)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CN(C)C=O>[CH2:20]([N:9]([CH2:8][CH2:7][CH2:6][N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1)[C:10](=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 3584880N-[3-(1H-imidazol-1-yl)propyl]benzamide

생성물 1

HCID 20248337N-Benzyl-N-[3-(1H-imidazol-1-yl)propyl]benzamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 4.58 g. of N-[3-(1H-imidazol-1-yl)propyl]benzamide, 40 ml. of dimethylformamide, and 0.96 g. of 50% sodium hydride in oil was stirred for 2 hours and 2.62 g. of benzyl bromide was added. The mixture was stirred for 24 hours, concentrated to remove the dimethyl formamide, diluted with water and methylene chloride, and the layers separated. The organic layer was washed with water, dried over magnesium sulfate, and concentrated. The oil was twice washed with hexane and again concentrated. The desired product was obtained as an oil.

후처리

  1. additionA mixture of 4.58 g
  2. concentrationconcentrated
  3. customto remove the dimethyl formamide
  4. additiondiluted with water and methylene chloride
  5. customthe layers separated
  6. washThe organic layer was washed with water
  7. dry with materialdried over magnesium sulfate
  8. concentrationconcentrated
  9. washThe oil was twice washed with hexane
  10. concentrationagain concentrated

출처 및 근거

ORD 기록
ord-305cdc4c88134a4bb37b46b9121669d9
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04568687

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