Hydrochloric Acid → Aditeren

HRID 1589247

반응식

HRID 1589247 반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9]O)=[CH:4][N:3]=1.NC1N=C(N)C(C#N)=CN=1.[CH3:21][O:22][C:23]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[C:24]=1[NH2:25].Cl>C(O)(=O)C>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][C:28]2[CH:27]=[C:26]([O:30][CH3:31])[C:24]([NH2:25])=[C:23]([O:22][CH3:21])[CH:29]=2)=[CH:4][N:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 95940Benzenamine, 2,6-dimethoxy-HCID 2821152,4-Diaminopyrimidine-5-carbonitrileHCID 2958782,4-Diamino-5-pyrimidinemethanol

생성물 1

HCID 176875Aditeren수율 86.3%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 2,4-diamino-5-hydroxymethylpyrimidine (4.30 g, 30.0 mmol), prepared from 2,4-diamino-5-cyanopyrimidine as described in U.K. Pat. No. 1 413 472, 2,6-dimethoxyaniline (5.05 g, 33.0 mmol), acetic acid (60 mL), and concentrated hydrochloric acid (4.2 mL) was refluxed for 41/2 hours, cooled, and filtered to give the hydrochloride salt of the title compound (7.13 g, 76.2%). The salt was dissolved in water and the solution made basic with concentrated ammonium hydroxide. The resulting precipitate was filtered, washed with water, and dried to give the title compound (5.18 g, 62.7%).

후처리

  1. temperaturecooled
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-ee60d8fc91e14d57a05c49a77102e768
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04568744

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