5-Bromo-6-fluoro-2-methylquinoline → 5-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

HRID 1589257노트

반응식

HRID 1589257 반응식
[Br:1][C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:13])=[N:7]2.[H][H]>C(O)(=O)C.[Pt]>[Br:1][C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH:6]([CH3:13])[NH:7]2

참가 물질

5

반응물 2

HCID 130353135-Bromo-6-fluoro-2-methylquinolineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 128968175-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 176Acetic Acid용매

실험 절차

To a solution of 20 g of 5-bromo-6-fluoroquinaldine in 150 ml of glacial acetic acid was added 2.0 g of platinum on charcoal. The mixture was hydrogenated on a Paar apparatus at a temperature of about 20° C. until the theoretical amount of hydrogen was taken up. The mixture was then filtered through celite to provide a solution of 5-bromo-6-fluoro-1,2,3,4-tetrahydroquinaldine. Evaporation of the solvent provides the desired intermediate. This intermediate could be used directly in Part C below without purification.

후처리

  1. filtrationThe mixture was then filtered through celite

출처 및 근거

ORD 기록
ord-e5af20ace377474ba08881a5e0eb9366
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04568750

반응 노트

불러오는 중…