Isopropyl isocyanate → 1-N-i-Propylcarbamoyloxindole

HRID 1589383

반응식

HRID 1589383 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH:11]([N:14]=[C:15]=[O:16])([CH3:13])[CH3:12]>C1(C)C=CC=CC=1>[CH:11]([NH:14][C:15]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10])=[O:16])([CH3:13])[CH3:12]

참가 물질

4

반응물 2

HCID 61277Isopropyl isocyanateHCID 321710Oxindole

생성물 1

HCID 135656731-N-i-Propylcarbamoyloxindole수율 85.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a stirred suspension of 5.0 g (37.6 mmole) of 2-oxindole in 50 ml of toluene was added 8.0 g (94.0 mmole) of isopropyl isocyanate, and the mixture was heated under reflux for 6 hours. The reaction mixture was allowed to cool and then it was stirred at room temperature overnight. The solvent was removed by evaporation in vacuo, and the residue was dissolved in hot cyclohexane. The solution was allowed to cool and the solid was collected by filtration, giving 7.0 g of the title compound, mp 84°-85.5° C., as pink crystals.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 6 hours
  3. temperatureto cool
  4. customThe solvent was removed by evaporation in vacuo
  5. dissolutionthe residue was dissolved in hot cyclohexane
  6. temperatureto cool
  7. filtrationthe solid was collected by filtration

출처 및 근거

ORD 기록
ord-6a442c4003c44daeb58d6b9920334144
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04569942

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