Ethanol → 3-Amino-6-(3-trifluoromethylphenyl)pyridazine

HRID 1589467노트

반응식

HRID 1589467 반응식
[NH:1]([C:3]1[N:4]=[N:5][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)=[CH:7][CH:8]=1)N.C(O)C.[H][H]>[Ni].O>[NH2:1][C:3]1[N:4]=[N:5][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:17])([F:16])[F:18])[CH:10]=2)=[CH:7][CH:8]=1

참가 물질

6

반응물 3

HCID 702EthanolHCID 127268553-Hydrazinyl-6-[3-(trifluoromethyl)phenyl]pyridazineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 135653673-Amino-6-(3-trifluoromethylphenyl)pyridazine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 962Water용매

실험 절차

Alternatively, 5.0 g of 3-hydrazino-6-[3-(trifluoromethyl)phenyl]pyridazine, 100 ml of ethanol, 10 ml of water and Raney nickel catalyst was shaken with hydrogen under 40 pounds of pressure in a Parr apparatus for 18 hours. The mixture was cooled and filtered and the filtrate concentrated to a gummy soid which was crystallized from dichloromethane-hexane to give 3-amino-6-[3-(trifluoromethyl)phenyl]pyridazine as off-white crystals, mp 138°-139° C.

후처리

  1. temperatureThe mixture was cooled
  2. filtrationfiltered
  3. concentrationthe filtrate concentrated to a gummy soid which
  4. customwas crystallized from dichloromethane-hexane

출처 및 근거

ORD 기록
ord-43f6a12e4a144161ad3d5225df8e846f
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04569934

반응 노트

불러오는 중…