Bromoacetone → 2-Methyl-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine hydrobromide

HRID 1589468노트

반응식

HRID 1589468 반응식
[NH2:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)=[CH:6][CH:7]=1.[Br:18][CH2:19][C:20](=O)[CH3:21]>C(O)C>[BrH:18].[CH3:21][C:20]1[N:1]=[C:2]2[CH:7]=[CH:6][C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:15])([F:17])[F:16])[CH:9]=3)=[N:4][N:3]2[CH:19]=1

참가 물질

4

반응물 2

HCID 11715BromoacetoneHCID 135653673-Amino-6-(3-trifluoromethylphenyl)pyridazine

생성물 1

HCID 135653662-Methyl-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine hydrobromide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A 1.5 g sample of 3-amino-6-[3-(trifluoromethyl)phenyl]pyridazine, 1.23 g of bromoacetone and 50 ml of ethanol was refluxed for 18 hours. The volatiles were removed in vacuo and the residue dissolved in dichloromethane. The solution was treated with activated carbon, filtered, and concentrated. The residue was crystallized from dichloromethane-hexane to give 1.0 g of the desired product as cream colored crystals, mp 219°-221° C.

후처리

  1. customThe volatiles were removed in vacuo
  2. dissolutionthe residue dissolved in dichloromethane
  3. additionThe solution was treated with activated carbon
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe residue was crystallized from dichloromethane-hexane

출처 및 근거

ORD 기록
ord-ebc16b882c6f455cae49408f6a73502d
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04569934

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