Acetic Anhydride → HCID 20246370, 화합물
반응식
[NH2:1][C:2]1[N:7]=[C:6]2[N:8]=[CH:9][CH:10]=[C:5]2[C:4](=[O:11])[N:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>N1C=CC=CC=1>[NH:1]([C:2]1[N:7]=[C:6]2[N:8]=[CH:9][CH:10]=[C:5]2[C:4](=[O:11])[N:3]=1)[C:12]([CH3:13])=[O:14]참가 물질
4
실험 절차
2-Aminopyrrolo(2,3-d)pyrimidin-4-one (3.0 g) and acetic anhydride (10 g) are suspended in pyridine (50 ml) and the reaction is conducted under reflux for 24 hours. The solvent and excess reagent are distilled off under reduced pressure and, on an ice bath, 5% (W/V) alcoholic ammonia (20 ml) is added to the residue. The mixture is stirred for 2 hours. The resulting crystalline precipitate is collected by filtration and washed with dilute hydrochloric acid and water to give the above-identified compound (2.5 g).
후처리
- temperatureunder reflux for 24 hours
- distillationThe solvent and excess reagent are distilled off under reduced pressure and, on an ice bath
- addition5% (W/V) alcoholic ammonia (20 ml) is added to the residue
- filtrationThe resulting crystalline precipitate is collected by filtration
- washwashed with dilute hydrochloric acid and water
출처 및 근거
- ORD 기록
- ord-7121e7973161421b9de70abbaca75120
- 출처 데이터셋
- uspto-grants-1986_02
- 특허 번호
- US04571423
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