Methacryloyl chloride → HCID 13627533, 화합물

HRID 1589615노트

반응식

HRID 1589615 반응식
[C:1]([C:3]1[C:8]([F:9])=[C:7]([F:10])[C:6]([OH:11])=[C:5]([F:12])[C:4]=1[F:13])#[N:2].[C:14](Cl)(=[O:18])[C:15]([CH3:17])=[CH2:16]>C(Cl)(Cl)(Cl)Cl>[C:14]([O:11][C:6]1[C:5]([F:12])=[C:4]([F:13])[C:3]([C:1]#[N:2])=[C:8]([F:9])[C:7]=1[F:10])(=[O:18])[C:15]([CH3:17])=[CH2:16]

참가 물질

4

반응물 2

HCID 13528Methacryloyl chlorideHCID 3613333Benzonitrile, 2,3,5,6-tetrafluoro-4-hydroxy-

생성물 1

HCID 13627533HCID 13627533, 화합물수율 83.8%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

In 200 ml of carbon tetrachloride, 19.1 g (0.100 mol) of 4-cyano-2,3,5,6-tetrafluorophenol and 13.0 g (0.125 mol) of methacrylic acid chloride were dissolved. To the resultant solution was added 20 g of molecular sieve 3 Å in diameter. The resultant mixture was refluxed as agitated for 48 hours. The reaction mixture so produced was cooled and then filtered to separate the molecular sieve. The filtrate was dried with magnesium sulfate and then evaporated to dryness with a rotary evaporator. Consequently, there was obtained 21.7 g of 4-cyano-2,3,5,6-tetrafluorophenyl methacrylate (yield 83.8% based on 4-cyano-2,3,5,6-tetrafluorophenol, purity 96.5%).

후처리

  1. customThe reaction mixture so produced
  2. temperaturewas cooled
  3. filtrationfiltered
  4. customto separate the molecular sieve
  5. dry with materialThe filtrate was dried with magnesium sulfate
  6. customevaporated to dryness with a rotary evaporator

출처 및 근거

ORD 기록
ord-f5d1d169c0c448b887376a42aed92100
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04572805

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