Benzene → HCID 13627534, 화합물

HRID 1589619노트

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HRID 1589619 반응식
[C:1]([C:3]1[C:8]([F:9])=[C:7]([F:10])[C:6]([OH:11])=[C:5]([F:12])[C:4]=1[F:13])#[N:2].[C:14](=[O:17])([O-])[O-].[Ca+2].Cl.[CH:20]1C=CC=C[CH:21]=1>>[C:14]([O:11][C:6]1[C:5]([F:12])=[C:4]([F:13])[C:3]([C:1]#[N:2])=[C:8]([F:9])[C:7]=1[F:10])(=[O:17])[CH:20]=[CH2:21]

참가 물질

5

반응물 4

HCID 241BenzeneHCID 313Hydrochloric AcidHCID 10112Calcium CarbonateHCID 3613333Benzonitrile, 2,3,5,6-tetrafluoro-4-hydroxy-

생성물 1

HCID 13627534HCID 13627534, 화합물수율 57.1%

실험 절차

In 30 ml of benzene, 3.82 g (0.020 mol) of 4-cyano-2,3,5,6-tetrafluorophenol and 2.26 g (0.025 mol) of calcium carbonate added thereto as a hydrogen chloride trapping agent were stirred under reflux for 40 hours. The resultant reaction mixture was cooled off and filtered to separate calcium carbonate. The filtrate was dried with magnesium sulfate and then evaporated to dryness with a rotary evaporator. Consequently, there was obtained 2.8 g of 4-cyano-2,3, 5,6-tetrafluorophenyl acrylate (yield 57.1%, purity 95.8%). The analyses obtained of the novel substance for the determination of its chemical structure were the same as those of Example 5.

후처리

  1. temperatureunder reflux for 40 hours
  2. customThe resultant reaction mixture
  3. temperaturewas cooled off
  4. filtrationfiltered
  5. customto separate calcium carbonate
  6. dry with materialThe filtrate was dried with magnesium sulfate
  7. customevaporated to dryness with a rotary evaporator

출처 및 근거

ORD 기록
ord-1cac325459d943e8af594be5dcaab32f
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04572805

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