Methanol → 2-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid

HRID 1589834노트

반응식

HRID 1589834 반응식
CO.[CH3:3][C:4]1[C:12]([C:13]([O:15]CC)=[O:14])=[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][N:6]2[N:5]=1>[OH-].[Na+]>[CH3:3][C:4]1[C:12]([C:13]([OH:15])=[O:14])=[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][N:6]2[N:5]=1

참가 물질

4

반응물 2

HCID 887MethanolHCID 12872285Ethyl 2-methylpyrazolo[1,5-a]pyridine-3-carboxylate

생성물 1

HCID 128722962-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid수율 52.4%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

A small amount of methanol was added to a solution of 0.356 g of ethyl 2-methyl-3-pyrazolo[1,5-a]-pyridinecarboxylate in 10 ml of 5N aq. NaOH solution, followed by stirring at room temperature for 24 hours. The reaction mixture was washed with benzene and then made acidic with concentrated hydrochloric acid. Crystals precipitated were collected by suction filtration. The crystals so obtained were dried and then recrystallized from benzene, whereby 0.16 g of the title compound was obtained (yield: 52.4%).

후처리

  1. washThe reaction mixture was washed with benzene
  2. customCrystals precipitated
  3. filtrationwere collected by suction filtration
  4. customThe crystals so obtained
  5. customwere dried
  6. customrecrystallized from benzene

출처 및 근거

ORD 기록
ord-ffa7cb32f58540528db749a437ea17ad
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05200415

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