Potassium Carbonate → 1-Methyloctahydropyrrolo[3,4-B]pyrrole

HRID 1590132노트

반응식

HRID 1590132 반응식
[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5](C(OCC)=O)[CH2:6]2.C(=O)([O-])[O-].[K+].[K+]>Cl>[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][NH:5][CH2:6]2

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 19100972Ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate

생성물 1

HCID 150700011-Methyloctahydropyrrolo[3,4-B]pyrrole

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

9 g (45.4 mmol) of ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate together with 50 ml of concentrated hydrochloric acid are refluxed overnight. The batch is rendered alkaline using potassium carbonate and extracted ten times using 50 ml portions of chloroform, and the extracts are dried over potassium carbonate, concentrated and distilled.

후처리

  1. extractionextracted ten times
  2. dry with materialthe extracts are dried over potassium carbonate
  3. concentrationconcentrated
  4. distillationdistilled

출처 및 근거

ORD 기록
ord-45f9503bc3fc42a991a37eb0c12b5839
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05202337

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