HCID 19100973, 화합물 → HCID 19100943, 화합물

HRID 1590153노트

반응식

HRID 1590153 반응식
[F:1][CH2:2][C:3]12[CH2:10][N:9](C(OCC)=O)[CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2>Cl>[F:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2

참가 물질

3

반응물 1

HCID 19100973HCID 19100973, 화합물

생성물 1

HCID 19100943HCID 19100943, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

7.1 g (26 mmol) of ethyl 5-fluoromethyl-2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate in 100 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is concentrated, the concentrate is taken up in 20 ml of water, this mixture is rendered alkaline using potassium carbonate and extracted ten times using 50 ml portions of chloroform, and the extracts are dried over potassium carbonate, concentrated and distilled.

후처리

  1. concentrationThe mixture is concentrated
  2. extractionextracted ten times
  3. dry with materialthe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationdistilled

출처 및 근거

ORD 기록
ord-41c40c9d8d41407098c78aa1908f7c6b
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05202337

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