Sodium Hydroxide → sodium (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate monohydrate

HRID 1590190노트

반응식

HRID 1590190 반응식
[CH2:1]([C@@H:8]([CH2:12][C:13]([N:15]1[CH2:23][C@H:22]2[C@H:17]([CH2:18][CH2:19][CH2:20][CH2:21]2)[CH2:16]1)=[O:14])[C:9]([OH:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+:25]>C(O)C>[OH2:10].[CH2:1]([C@@H:8]([CH2:12][C:13]([N:15]1[CH2:16][C@H:17]2[C@H:22]([CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:23]1)=[O:14])[C:9]([O-:11])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[Na+:25]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 121891Mitiglinide

생성물 1

HCID 67758743sodium (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate monohydrate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid (1.38 g) in ethanol (5 ml) was added 2N sodium hydroxide solution (2.19 ml). After the solvent was evaporated under reduced pressure, the residue was crystallized from ethyl acetate to give 1.44 g of sodium (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate monohydrate.

후처리

  1. customAfter the solvent was evaporated under reduced pressure
  2. customthe residue was crystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-84ea975f100642eaa913f532cc042a2e
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05202335

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