Diethyl Ether → HCID 57153373, 화합물

HRID 1590265

반응식

HRID 1590265 반응식
[C:1]1([N:7]2[CH2:11][CH2:10][C:9](=O)[C:8]2=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:14][N:15]1[CH2:19][CH2:18][CH2:17][CH:16]1[CH2:20][O:21][CH3:22].CCOCC>C1C=CC=CC=1>[CH3:22][O:21][CH2:20][CH:16]1[CH2:17][CH2:18][CH2:19][N:15]1[N:14]=[C:9]1[CH2:10][CH2:11][N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:8]1=[O:13]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 1436632-(Methoxymethyl)pyrrolidin-1-amineHCID 190235711-Phenylpyrrolidine-2,3-dione

생성물 1

HCID 57153373HCID 57153373, 화합물

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A solution of the product of Example 61 and chiral 1-amino-2-methoxymethylpyrrolidine (SAMP or RAMP; 1 equiv) in benzene is refluxed under Dean-Stark conditions for 20 h After cooling, Et2O is added and the mixture is washed with water. The organic layer is dried (MgO4), and evaporated to give a residue which is chromatographed on silica gel to give the title compound.

후처리

  1. temperatureAfter cooling
  2. washthe mixture is washed with water
  3. customThe organic layer is dried (MgO4)
  4. customevaporated
  5. customto give a residue which
  6. customis chromatographed on silica gel

출처 및 근거

ORD 기록
ord-4025d25706be4a47bd53045e959c41ba
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05202344

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