HCID 3265055, 화합물 → 8-Fluoro-1,2,3,9-tetrahydro-4H-carbazol-4-one
반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[CH2:14][CH2:13][CH2:12][C:11](=[O:15])[CH:10]=1>CN(C=O)C.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[NH:8][C:9]1[CH2:14][CH2:13][CH2:12][C:11](=[O:15])[C:10]2=1참가 물질
5
실험 절차
3-[(2-Fluorophenyl)amino]-2-cyclohexen-1-one (14.8 g), palladium (II) acetate (1 g), and copper (II) acetate (29.5 g) were heated together in DMF (100 ml) under nitrogen at 140° for 2 h. The solvent was removed in vacuo, and the residue was purified by FCC eluting with ether to give the title compound (10.1 g), m.p. 222°-224°.
후처리
- customThe solvent was removed in vacuo
- customthe residue was purified by FCC
- washeluting with ether
출처 및 근거
- ORD 기록
- ord-7a17cc3614bd467ea4c8c7debbbc2dcf
- 출처 데이터셋
- uspto-grants-1993_04
- 특허 번호
- US05202343
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