4-Acetamido-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine → 4-Amino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine

HRID 1590947노트

반응식

HRID 1590947 반응식
C([NH:4][CH:5]1[CH2:10][C:9]([CH3:12])([CH3:11])[N:8]([O:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:7]([CH3:21])([CH3:20])[CH2:6]1)(=O)C>O.Cl>[NH2:4][CH:5]1[CH2:10][C:9]([CH3:11])([CH3:12])[N:8]([O:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:7]([CH3:21])([CH3:20])[CH2:6]1

참가 물질

4

반응물 1

HCID 233721204-Acetamido-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine

생성물 1

HCID 222779844-Amino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매

실험 절차

A solution of 5.0 g of the acetamide from Example 47 in 7.5 ml of water and 7.5 ml of conc. hydrochloric acid is heated at reflux for 10 hours. The reaction mixture is then quenched with saturated sodium carbonate and extracted with ethyl acetate. The combined organic extracts are washed with water, brine, dried (MgSO4) and evaporated to leave a light brown oil. Distillation (Kugelrohr, 140° C. @ 1.5 mm) affords the title compound as a clear colorless oil.

후처리

  1. temperatureat reflux for 10 hours
  2. customThe reaction mixture is then quenched with saturated sodium carbonate
  3. extractionextracted with ethyl acetate
  4. washThe combined organic extracts are washed with water, brine
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. customto leave a light brown oil
  8. distillationDistillation (Kugelrohr, 140° C. @ 1.5 mm)

출처 및 근거

ORD 기록
ord-20400bae19bc435083a1307f1c5118eb
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05204473

반응 노트

불러오는 중…