Propylene Oxide → alpha(or beta)-methyl-1H-imidazole-1-ethanol

HRID 1591072노트

반응식

HRID 1591072 반응식
Cl.[N:2]1([CH2:7][CH:8]([CH3:14])[O:9][CH2:10][C:11]([OH:13])=[O:12])[CH:6]=[CH:5][N:4]=[CH:3]1.[Na].O[C:17](P(O)(=O)O)(P(O)(=O)O)COC(C)CN1C=CN=C1.[CH2:36]1O[CH:37]1C>>[N:2]1([CH:7]([CH3:17])[CH2:8][OH:9])[CH:6]=[CH:5][N:4]=[CH:3]1.[CH2:36]([O:12][C:11](=[O:13])[CH2:10][O:9][CH:8]([CH3:14])[CH2:7][N:2]1[CH:6]=[CH:5][N:4]=[CH:3]1)[CH3:37]

참가 물질

6

반응물 4

HCID 6378Propylene OxideHCID 5360545SodiumHCID 197663375-(Imidazol-1-yl)-4-methyl-3-oxa-pentanoic acid-hydrochlorideHCID 197663941-Hydroxy-5-(imidazol-1-yl)-4-methyl-3-oxa-pentane-1,1-diphosphonic acid

생성물 2

HCID 109147alpha(or beta)-methyl-1H-imidazole-1-ethanolHCID 179907055-(Imidazol-1-yl)-4-methyl-3-oxa-pentanoic acid-ethyl ester

실험 절차

The 5-(imidazol-1-yl)-4-methyl-3-oxa-pentanoic acid-hydrochloride used as the starting material was prepared in the following manner: reaction of the sodium salt of the imidazole with propene oxide yields the 2-(imidazol-1-yl)-1-propanol (b.p.0.1 : 147°-150° C.) from which the 5-(imidazol-1-yl)-4-methyl-3-oxa-pentanoic acid-ethyl ester (oil) is obtained by reaction with ethyl bromoacetate in dimethyl formamide in the presence of sodium hydride which is then saponified with 3N hydrochloric acid to form the desired acid.

후처리

  1. customwas prepared in the following manner

출처 및 근거

ORD 기록
ord-b5100ed72aef45b9b741de2fb1877cdf
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05206253

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