Hydrochloric Acid → 2-(2,6-Dichloro-4-trifluoromethylphenyl)-imidazole-4,5-dicarboxamide

HRID 1591089노트

반응식

HRID 1591089 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4](Cl)[C:3]=1[C:13]1[NH:14][C:15]([C:20]#[N:21])=[C:16]([C:18]#[N:19])[N:17]=1.[OH-:22].[K+].[ClH:24].C([OH:27])C>O>[Cl:24][C:4]1[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=[C:2]([Cl:1])[C:3]=1[C:13]1[NH:14][C:15]([C:20]([NH2:21])=[O:27])=[C:16]([C:18]([NH2:19])=[O:22])[N:17]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 189476852-(2,6-Dichloro-4-trifluoromethylphenyl)-4,5-dicyanoimidazole

생성물 1

HCID 189476912-(2,6-Dichloro-4-trifluoromethylphenyl)-imidazole-4,5-dicarboxamide

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of 2-(2,6-dichloro-4-trifluoromethylphenyl)-4,5-dicyanoimidazole (3.3 g, 0.01 mol) and potassium hydroxide (85%, 1.64 g, 0.025 mol) in ethanol (20 ml) and water (2 ml) was heated at reflux for 3.5 hours. After cooling the mixture was poured into water (100 ml) and acidified to pH1 by the addition of concentrated hydrochloric acid. The precipitated solid was filtered off and dried at 80° C. and 10 mm Hg to give 2-(2,6-dichloro-4-trifluoromethylphenyl)-imidazole-4,5-dicarboxamide (0.6 g), m.p. 306°-308° C., as an off white solid.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 3.5 hours
  3. temperatureAfter cooling the mixture
  4. filtrationThe precipitated solid was filtered off
  5. customdried at 80° C.

출처 및 근거

ORD 기록
ord-193ee0310a2740ecaa8efac82a5b674f
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05206257

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