4-(Trifluoromethyl)benzaldehyde → 4-Methylbenzotrifluoride

HRID 1591099

반응식

HRID 1591099 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][CH:4]=1.[H][H]>C(O)(=O)C.[Pt]>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:4]=[CH:5][C:6]([CH3:7])=[CH:9][CH:10]=1

참가 물질

5

반응물 2

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 802304-Methylbenzotrifluoride수율 77.7%

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 176Acetic Acid용매

실험 절차

4-Trifluoromethylbenzaldehyde (20.0 g) was dissolved in acetic acid (100 ml) and treated with hydrogen in the presence of platinum (0.5 g) at ambient temperature and pressure for 10 hours. The solution was filtered, poured into water (400 ml), basified by addition of aqueous sodium hydroxide solution (2 M), extracted with ether (3×100 ml). The combined extracts were washed with water (2×100 ml), dried over anhydrous magnesium sulphate, evaporated to dryness. The residue was distilled to give 4-trifluoromethyltoluene (14.3 g) b.p. 131°-132° C. as a colourless mobil liquid.

후처리

  1. filtrationThe solution was filtered
  2. additionpoured into water (400 ml)
  3. additionbasified by addition of aqueous sodium hydroxide solution (2 M)
  4. extractionextracted with ether (3×100 ml)
  5. washThe combined extracts were washed with water (2×100 ml)
  6. dry with materialdried over anhydrous magnesium sulphate
  7. customevaporated to dryness
  8. distillationThe residue was distilled

출처 및 근거

ORD 기록
ord-0a022bef1b89428289817bea16278ad2
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05206257

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