Formic Acid → 1-Pentanol

HRID 1591284노트

반응식

HRID 1591284 반응식
[CH:1](O)=[O:2].C(O[C:8](=[O:10])[CH3:9])(=O)C.[NH2:11][C:12]1[S:13][CH:14]=[C:15]([O:19][CH2:20][CH3:21])[C:16]=1[C:17]#[N:18]>O>[CH:1]([NH:11][C:12]1[S:13][CH:14]=[C:15]([O:19][CH2:20][CH3:21])[C:16]=1[C:17]#[N:18])=[O:2].[CH2:8]([OH:10])[CH2:9][CH2:14][CH2:15][CH3:16]

참가 물질

6

반응물 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 137423802-Amino-4-ethoxythiophene-3-carbonitrile

생성물 2

HCID 62761-PentanolHCID 13742382HCID 13742382, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

200 parts of formic acid are added dropwise to 500 parts of acetic anhydride at room temperature, and 168 parts of 2-amino-3-cyano-4-ethoxythiophene are introduced after 2 hours. The mixture is stirred for 4 hours at 50° C., after which 1000 parts of water are run into the hot mixture. The mixture is cooled and the product is then filtered off under suction, washed with water and dried. 174 parts of 2-formylamino-3-cyano-4-ethoxythiophene of melting point 191°-192° C. (from pentanol) are obtained.

후처리

  1. temperatureThe mixture is cooled
  2. filtrationthe product is then filtered off under suction
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-8a91f6767cb24a1ebf79699d8a5ea29b
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05206375

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