Methyl iodide → 1-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one

HRID 1591327노트

반응식

HRID 1591327 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH2:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1.I[CH3:19]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH:10]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[CH3:19]

참가 물질

3

반응물 2

HCID 6328Methyl iodideHCID 189565241-(2,4-Difluorophenyl)-2-(3-pyridinyl)-ethanone

생성물 1

HCID 189565411-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one수율 73.6%

실험 절차

Methylation of the product of part (i) (5.0 g) with iodomethane (7.60 g) according to the method of Example 11(ii) gave the title compound as an oil (3.90 g) which was used directly in the next stage.

출처 및 근거

ORD 기록
ord-fb654f5d6f7d43dc8a492bf02a39af0c
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05206364

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