Sodium borohydride → (4-[1,2,3]Triazol-2-yl-phenyl)-methanol
반응식
[N:1]1[N:2]([C:6]2[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[CH:8][CH:7]=2)[N:3]=[CH:4][CH:5]=1.[BH4-].[Na+]>C1COCC1.CO>[N:1]1[N:2]([C:6]2[CH:7]=[CH:8][C:9]([CH2:10][OH:11])=[CH:12][CH:13]=2)[N:3]=[CH:4][CH:5]=1참가 물질
5
실험 절차
To a solution of 42.26 g (244 mmol) of 4-[1,2,3]-triazol-2-yl-benzaldehyde in 140 ml of THF and 420 ml of MeOH, 9.23 g (244 mmol) of NaBH4 are added portionwise at 0-5° C. and the mixture is stirred for 30 min. at the same temperature. The reaction is quenched with sat. NH4Cl at 0-5° C. and the mixture is extracted with AcOEt. The combined extracts are washed with brine, dried over MgSO4 and concentrated under reduced pressure to give the title compound as a colorless solid.
후처리
- customThe reaction is quenched with sat. NH4Cl at 0-5° C.
- extractionthe mixture is extracted with AcOEt
- washThe combined extracts are washed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-f09b7bc3af6841a98bb1913ee8b3dc4a
- 출처 데이터셋
- uspto-grants-2007_11
- 특허 번호
- US07291634B2
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