Hydrochloric Acid → 6-Fluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][C:7](=[N:12]O)[CH2:6][CH2:5]2.[ClH:14]>[Pd].CO>[ClH:14].[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([NH2:12])[CH2:6][CH2:5]2참가 물질
5
실험 절차
A mixture of 6-fluoro-3,4-dihydronaphthalen-2(1H)-one oxime (1.58 g, 8.81 mmol), methanol (25 mL), conentrated hydrochloric acid (2 mL) and 10% palladium on charcoal (316 mg) was shaken in a pressure bottle under a hydrogen atmosphere (55 psig). After 18 hours, the mixture was filtered and the solid washed with methanol. The filtrate was concentrated under vacuum, and the residue was washed with ether, dried by concentration from benzene, and dried further under vacuum to provide a white solid (1.48 g, 83%).
후처리
- filtrationthe mixture was filtered
- washthe solid washed with methanol
- concentrationThe filtrate was concentrated under vacuum
- washthe residue was washed with ether
- dry with materialdried by concentration from benzene
- customdried further under vacuum
출처 및 근거
- ORD 기록
- ord-585afe5e44ee4a9c8b76bd8f4bd5ae18
- 출처 데이터셋
- uspto-grants-2007_11
- 특허 번호
- US07291744B2
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