Sodium Hydroxide → HCID 17952314, 화합물
반응식
C[O:2][C:3](=[O:17])[CH2:4][CH:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][N:6]1[CH:14]([CH3:16])[CH3:15].[OH-].[Na+]>CO>[CH:14]([N:6]1[CH2:7][C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]1[CH2:4][C:3]([OH:17])=[O:2])([CH3:16])[CH3:15]참가 물질
4
실험 절차
To the compound of Step B (0.53 g., 2.30 mmol) in MeOH (5.1 mL) was added 1.0N NaOH (2.53 mL, 2.53 mmol). After two days, the solution was concentrated to dryness. The resulting residue was diluted with 1.0N HCl and water was loaded onto a strong cation exchange resin. The resin was washed with water, TBF/water (1:1) and then water. The product was then eluted from the resin with pyridine/water (1:9). The eluent was concentrated to dryness to afford about 0.43 g (85%) of the final compound. EIS-MS 220 [M+1].
후처리
- concentrationthe solution was concentrated to dryness
- additionThe resulting residue was diluted with 1.0N HCl and water
- washThe resin was washed with water, TBF/water (1:1)
- washThe product was then eluted from the resin with pyridine/water (1:9)
- concentrationThe eluent was concentrated to dryness
출처 및 근거
- ORD 기록
- ord-82ed703795084fc9ac27e2d42f8b82c0
- 출처 데이터셋
- uspto-grants-2007_11
- 특허 번호
- US07291619B2
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