Sodium Hydroxide → N-(4-methoxyphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine

HRID 1592967

반응식

HRID 1592967 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)=O.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20]([NH2:22])=[S:21])=[CH:15][CH:14]=1.[OH-].[Na+]>O.CCO>[CH3:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([NH:19][C:20]2[S:21][CH:2]=[C:3]([C:5]3[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=3)[N:22]=2)=[CH:17][CH:18]=1

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 4070312-Bromo-1-(pyridin-4-yl)ethanoneHCID 6675494-Thioureidoanisole

생성물 1

HCID 793675N-(4-methoxyphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매2회

실험 절차

To a solution of 3.0 g (15 mmol) 4-(2-bromo)acetylpyridine (6-2) in 50 mL water was added an equimolar amount of 4-methoxyphenylthiourea (7-1; 2.75 g). The reaction was diluted with 20 mL EtOH. The reaction was allowed to stir at rt overnight, over which time a color change occurred from clear to a thick orange precipitate. The reaction mixture was diluted with 100 mL water then the pH was adjusted to neutral with 1N NaOH. The reaction was allowed to stir at rt and a large amount of precipitate formed which was collected by filtration. The resulting powder was dried under high vacuum to yield N-(4-methoxyphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine (7-2): 1H NMR (500 MHz, CD3OD) δ 8.98 (d, J=3 Hz, 2H), 8.10 (d, J=3 Hz, 2H), 7.53 (s, 1H), 3.0 (s, 3H): MS 284.3 found 284.2 (M+H+).

후처리

  1. stirringto stir at rt
  2. customa large amount of precipitate formed which
  3. filtrationwas collected by filtration
  4. customThe resulting powder was dried under high vacuum

출처 및 근거

ORD 기록
ord-a5e9366d433941d3b9570efba81fe766
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07294640B2

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