Hydrochloric Acid → HCID 45094991, 화합물

HRID 1593022노트

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HRID 1593022 반응식
[CH2:1]([CH:3]1[C:7](=[O:8])[N:6]([CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[C:5](=[O:22])[NH:4]1)[CH3:2].Cl.C(OCC)C>O1CCOCC1>[CH2:1]([CH:3]1[NH:4][C:5](=[O:22])[N:6]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[C:7]1=[O:8])[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 69448964HCID 69448964, 화합물

생성물 1

HCID 45094991HCID 45094991, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a suspension of tert-butyl 4-(4-ethyl-2,5-dioxoimidazolidin-1-yl)piperidine-1-carboxylate (1.12 g) in dioxane (10 ml) was added a solution of 4M HCl in dioxane (10 ml) and the resulting mixture was stirred for 1 hour. Diethyl ether (20 ml) was added and the mixture was filtered and washed with diethyl ether to give 5-ethyl-3-piperidin-4-ylimidazolidine-2,4-dione. Yield 687 mg. MS 212 MH+

후처리

  1. filtrationthe mixture was filtered
  2. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-eb36e12cfd174a43ad4c119609322543
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07294636B2

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