Sodium Hydroxide → 2-(2-Chlorophenyl)-5-methyl-1H-imidazole-4-carboxylic acid

HRID 1593132노트

반응식

HRID 1593132 반응식
C([O:3][C:4]([C:6]1[N:7]=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])[NH:9][C:10]=1[CH3:11])=[O:5])C.[OH-].[Na+]>C(O)C>[Cl:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:8]1[NH:9][C:10]([CH3:11])=[C:6]([C:4]([OH:5])=[O:3])[N:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 43445075HCID 43445075, 화합물

생성물 1

HCID 434450792-(2-Chlorophenyl)-5-methyl-1H-imidazole-4-carboxylic acid수율 89.9%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
95 °C

실험 절차

To 11.2 g of 2-(2-chloro-phenyl)-5-methyl-1H-imidazole-4-carboxylic acid ethyl ester in 150 ml of ethanol was added 80 ml of a 2N-NaOH solution and the reaction mixture was stirred at 95° C. for 17 hours. After such time ethanol was removed in vacuo and the remaining aqueous solution was treated with a 2N HCl solution until obtaining pH=3. The precipitate was filtered and dried under high vacuum to yield 9.0 g of a pale yellow powder.

후처리

  1. customAfter such time ethanol was removed in vacuo
  2. additionthe remaining aqueous solution was treated with a 2N HCl solution
  3. customuntil obtaining pH=3
  4. filtrationThe precipitate was filtered
  5. customdried under high vacuum

출처 및 근거

ORD 기록
ord-53cac2380de240f2ac157ea66b146f6b
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07294644B2

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