Sodium Hydroxide → 2-Methylpyrimidine-5-carboxylic acid

HRID 1593384노트

반응식

HRID 1593384 반응식
[OH-].[Na+].[CH3:3][C:4]1[N:9]=[CH:8][C:7]([C:10]([O:12]CC)=[O:11])=[CH:6][N:5]=1>C(O)C>[CH3:3][C:4]1[N:9]=[CH:8][C:7]([C:10]([OH:12])=[O:11])=[CH:6][N:5]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 14639203Ethyl 2-methylpyrimidine-5-carboxylate

생성물 1

HCID 136708752-Methylpyrimidine-5-carboxylic acid수율 78.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In 30 ml of ethanol and 20 ml of a 1M sodium hydroxide aqueous solution, 2.9 g of ethyl 2-methylpyrimidine-5-carboxylate was stirred for 2 hours. The solvent was removed by evaporation and an appropriate amount of water and diethyl ether were added thereto, followed by liquid-separating operation. The resulting aqueous layer was made weakly acidic with a 1M hydrochloric acid aqueous solution and then the resulting crystals were collected by filtration, washed with water, and then dried to obtain 1.9 g of the title compound.

후처리

  1. customThe solvent was removed by evaporation
  2. additionan appropriate amount of water and diethyl ether were added
  3. customby liquid-separating operation
  4. filtrationthe resulting crystals were collected by filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-30401727b2c744078950f7a1fde32c60
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07297698B2

반응 노트

불러오는 중…