Hydrochloric Acid → 2-Cyclopropylquinazoline-6-carboxylic acid
반응식
C[CH:2]([OH:4])[CH3:3].[CH:5]1([C:8]2[N:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=C(C#N)[CH:14]=3)[N:9]=2)[CH2:7][CH2:6]1.[OH-:20].[K+].Cl>O>[CH:5]1([C:8]2[N:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:3]([C:2]([OH:4])=[O:20])[CH:14]=3)[N:9]=2)[CH2:7][CH2:6]1참가 물질
6
실험 절차
Into 8 ml of 2-propanol and 1 ml of water were dissolved 210 mg of 2-cyclopropylquinazoline-6-carbonitrile and 450 mg of potassium hydroxide, followed by heating under refluxing overnight. Hydrochloric acid was added thereto and the solvent was removed by evaporation to obtain the title compound as a crude carboxylic acid.
후처리
- temperatureby heating
- temperatureunder refluxing overnight
- customthe solvent was removed by evaporation
출처 및 근거
- ORD 기록
- ord-bc5bbe1747a94d5eb61ba7ee5ccd0dc9
- 출처 데이터셋
- uspto-grants-2007_11
- 특허 번호
- US07297698B2
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