Ammonium formate → HCID 10934154, 화합물

HRID 1593477노트

반응식

HRID 1593477 반응식
C1([C@@H]([NH:9][C@H:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:12][C@@H:11]2[C:23]([O:25][CH3:26])=[O:24])C)C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[NH2:9][C@H:10]1[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:17])[CH2:12][C@@H:11]1[C:23]([O:25][CH3:26])=[O:24]

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 58745501HCID 58745501, 화합물

생성물 1

HCID 10934154HCID 10934154, 화합물수율 96%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 260A (1.10 g, 3.03 mmol) in MeOH (31 mL) at room temperature was treated with ammonium formate (1.51 g, 24.3 mmol) and 10% Pd/C (110 mg). The reaction mixture was heated to reflux for 14 hours then cooled to room temperature. The solid material was removed by filtration and washed with MeOH. The filtrate was concentrated in vacuo to give 0.75 g (yield: 96%) of Compound 260B as an oil.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 14 hours
  3. customThe solid material was removed by filtration
  4. washwashed with MeOH
  5. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-89d2a62411554ddba61dab644476d38b
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07297695B2

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