Bromine → 5-Bromo-2-hydroxypyridine-3-carbonitrile

HRID 1593669

반응식

HRID 1593669 반응식
[Br:1]Br.[O:3]=[C:4]1[C:9]([C:10]#[N:11])=[CH:8][CH:7]=[CH:6][NH:5]1>C(O)(=O)C>[Br:1][C:7]1[CH:8]=[C:9]([C:10]#[N:11])[C:4](=[O:3])[NH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 5775433-Cyano-2-pyridone

생성물 1

HCID 72048705-Bromo-2-hydroxypyridine-3-carbonitrile

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Bromine (29 ml, 560 mmol) was added to a stirred solution of 2-oxo-1,2-dihydro-pyridine-3-carbonitrile (34 g, 280 mmol) in acetic acid (180 ml) at room temperature. After 14 hours the reaction mixture was concentrated in vacuo and the resulting oil was trituated with ethanol to afford the title compound as a solid.

후처리

  1. concentrationAfter 14 hours the reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-bad87c6cf601468b882f553d00f8474a
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07297792B2

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