Hydrochloric Acid → 3-(n-((2-(2-Carboxyphenyl)phenyl)carbonyl)-n-(2-(4-ethoxyphenyl)ethyl)amino)propanoic acidethyl ester

HRID 1594185노트

반응식

HRID 1594185 반응식
ClC1C=CC(CNC(C2C=CC=CC=2C2C=CC=CC=2C([N:24]([CH2:35][CH2:36][C:37]([OH:39])=[O:38])[CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2OC)=O)=O)=CC=1.[C:42]12[C:49]3=[CH:50][CH:51]=[CH:52][CH:53]=[C:48]3[C:47](=[O:54])[O:46][C:44](=[O:45])[C:43]1=[CH:55][CH:56]=[CH:57][CH:58]=2.[CH2:59](N(CC)CC)[CH3:60].Cl.[C:67](OCC)(=[O:69])[CH3:68]>C(Cl)Cl>[CH2:59]([O:39][C:37](=[O:38])[CH2:36][CH2:35][N:24]([C:47]([C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][C:49]=1[C:42]1[CH:58]=[CH:57][CH:56]=[CH:55][C:43]=1[C:44]([OH:46])=[O:45])=[O:54])[CH2:25][CH2:26][C:27]1[CH:28]=[CH:29][C:30]([O:69][CH2:67][CH3:68])=[CH:31][CH:32]=1)[CH3:60]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 72794Diphenic anhydrideHCID 230791343-(n-((2-(2-((4-Chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-n-(2-(2-methoxyphenyl)ethyl)amino)propanoic acid

생성물 1

HCID 692464633-(n-((2-(2-Carboxyphenyl)phenyl)carbonyl)-n-(2-(4-ethoxyphenyl)ethyl)amino)propanoic acidethyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The compound prepared in reference example 1 (600 mg), diphenic anhydride (538 mg) and triethylamine (0.85 ml) were dissolved in methylene chloride (10 ml) and the mixture was stirred overnight at room temperature. The reaction mixture was poured into a mixture of ethyl acetate and 1N hydrochloric acid, and the aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with a saturated aqueous solution of sodium bicarbonate and brine successively and dried over anhydrous sodium sulfate. The solvent was evaporated to give the title compound (837 mg) having the following physical data.

후처리

  1. extractionthe aqueous layer was extracted with ethyl acetate
  2. washThe combined organic layer was washed with a saturated aqueous solution of sodium bicarbonate and brine successively
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-2eeb114e530a41dfb41d22137bc8dde7
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07300917B2

반응 노트

불러오는 중…