m-Chloroperbenzoic acid → 3-Methylsulfonyl-5-(cyclohexyl)methyl-1,2,4-thiadiazole

HRID 1594419노트

반응식

HRID 1594419 반응식
CS[C:3]1[N:7]=[C:6]([CH2:8][CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[S:5][N:4]=1.Cl[C:16]1C=C(C=CC=1)C(OO)=O.[S:26]([O-:29])(O)=[O:27].[Na+]>C(Cl)(Cl)Cl>[CH3:16][S:26]([C:3]1[N:7]=[C:6]([CH2:8][CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[S:5][N:4]=1)(=[O:29])=[O:27]

참가 물질

5

반응물 3

HCID 70297m-Chloroperbenzoic acidHCID 23665763Sodium BisulfiteHCID 586104393-Methylthio-5-(cyclohexyl)methyl-1,2,4-thiadiazole

생성물 1

HCID 690245423-Methylsulfonyl-5-(cyclohexyl)methyl-1,2,4-thiadiazole

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

1.2 g of 3-methylthio-5-(cyclohexyl)methyl-1,2,4-thiadiazole was dissolved in 20 ml of chloroform, 2.78 g of 3-chloroperoxybenzoic acid (content>65%) was added thereto, and the reaction mixture was stirred for 1 hour under ice-cooling and for 16 hours at room temperature. Then, the reaction mixture was added to saturated sodium hydrogensulfite aqueous solution, and separated. The organic layer was washed with sodium hydrogencarbonate aqueous solution, dried over anhydrous sodium sulfate, concentrated to give 1.4 g of 3-methylsulfonyl-5-(cyclohexyl)methyl-1,2,4-thiadiazole.

후처리

  1. customseparated
  2. washThe organic layer was washed with sodium hydrogencarbonate aqueous solution
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-59a78a59556248c28fc5abf310fb4ea5
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07301032B2

반응 노트

불러오는 중…