Hydrochloric Acid → (-)-1-Methyl-3-phenylpropylamine

HRID 1594554노트

반응식

COCC([NH:6][C@H:7]([CH3:16])[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=O.Cl>>[CH3:16][C@@H:7]([NH2:6])[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 23627162HCID 23627162, 화합물

생성물 1

HCID 2734033(-)-1-Methyl-3-phenylpropylamine수율 100.2%

실험 절차

This gives 7.4 g (96.25 % ee, 84% of theory) of (R)-N-methoxyacetyl-1-methyl-3-phenyl-propylamine, which is then heated under reflux with 50 ml of 18% strength aqueous hydrochloric acid for 4 hours. Work-up gives 5.0 g (96% ee, 98% of theory) of (R)-1-methyl-3-phenyl-propylamine.

출처 및 근거

ORD 기록: ord-02cc6d23d55f4629bf99e0469810f943
출처 데이터셋: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06284710B1

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