Sodium Bicarbonate → 1-(4-Methoxybenzyl)-5-bromo-4-methyl-3-amino-2-pyridone

HRID 1594665노트

반응식

HRID 1594665 반응식
[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([CH2:7][N:8]2[CH:13]=[C:12]([Br:14])[C:11]([CH3:15])=[C:10]([N+:16]([O-])=O)[C:9]2=[O:19])=[CH:5][CH:4]=1.C([O-])(O)=O.[Na+]>C(O)(=O)C.Cl.O>[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([CH2:7][N:8]2[CH:13]=[C:12]([Br:14])[C:11]([CH3:15])=[C:10]([NH2:16])[C:9]2=[O:19])=[CH:5][CH:4]=1

참가 물질

6

반응물 2

HCID 516892Sodium BicarbonateHCID 217064791-(4-Methoxybenzyl)-5-bromo-4-methyl-3-nitro-2-pyridone

생성물 1

HCID 217064931-(4-Methoxybenzyl)-5-bromo-4-methyl-3-amino-2-pyridone수율 61.5%

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 313Hydrochloric Acid용매HCID 962Water용매

실험 절차

To a stirred solution of 1-(4-methoxybenzyl)-5-bromo-4-methyl-3-nitro-2-pyridone (0.23 g 0.65 mmol) in glacial acetic acid (3 mL) was added a solution of stannous chloride dihydrate (1.0 g) in concentrated HCl (2 mL). After 3.5 hours, the reaction mixture was diluted with water, neutralized with NaHCO3, and extracted with methylene chloride. The organic phase was dried, filtered, and evaporated to give 1-(4-methoxybenzyl)-5-bromo-4-methyl-3-amino-2-pyridone (0.13 g, 0.40 mmol, 61%).

후처리

  1. extractionextracted with methylene chloride
  2. customThe organic phase was dried
  3. filtrationfiltered
  4. customevaporated

출처 및 근거

ORD 기록
ord-d1305c411cdf4f59b54002cc1c333e84
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06284768B1

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