Water → Cyclohexanone, 2-(3-methoxyphenyl)-, oxime

HRID 1594919노트

반응식

HRID 1594919 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]2=O)[CH:6]=[CH:7][CH:8]=1.Cl.[NH2:17][OH:18].C([O-])(=O)C.[Na+].O>CCO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]2=[N:17][OH:18])[CH:6]=[CH:7][CH:8]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 858682-(3-Methoxyphenyl)cyclohexanoneHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 2728109Cyclohexanone, 2-(3-methoxyphenyl)-, oxime

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-(3-Methoxyphenyl)-cyclohexanone, as described in Step A above, (0.61 g, 3 mmol), hydroxylamine hydrochloride (0.40 g, 6 mmol) and sodium acetate (0.80, 6.2 mmol) were combined in EtOH (4 mL): H2O (2 mL) and heated at reflux for 3 h. The reaction mixture was concentrated, then partitioned between EtOAc (100 mL) and H2O (100 mL), the organic layer separated, washed with H2O, brine, and dried (MgSO4). Filtration and concentration to dryness gave the title compound.

후처리

  1. temperatureat reflux for 3 h
  2. concentrationThe reaction mixture was concentrated
  3. custompartitioned between EtOAc (100 mL) and H2O (100 mL)
  4. customthe organic layer separated
  5. washwashed with H2O, brine
  6. dry with materialdried (MgSO4)
  7. filtrationFiltration and concentration to dryness

출처 및 근거

ORD 기록
ord-0723351be00e4feaab4906a065b4772b
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06284755B1

반응 노트

불러오는 중…