Boron tribromide → HCID 21706255, 화합물

HRID 1594922노트

반응식

HRID 1594922 반응식
B(Br)(Br)Br.[CH3:5][C:6]1([CH:14]2[NH:20][C:19](=[O:21])[CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:11]=[CH:10][CH:9]=[C:8]([O:12]C)[CH2:7]1>C(Cl)(Cl)Cl>[CH3:5][C:6]1([CH:14]2[NH:20][C:19](=[O:21])[CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:11]=[CH:10][CH:9]=[C:8]([OH:12])[CH2:7]1

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 21706269HCID 21706269, 화합물

생성물 1

HCID 21706255HCID 21706255, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

BBr3 (1M in CH2Cl2) (1 mL, 1 mmol) was added dropwise to a solution of 7-(1-methyl-3-methoxyphenyl)-azepan-2-one, as described in Step D above, (0.06 g, 0.26 mmol) in CHCl3 (1 mL) at 0° C. with stirring. The ice bath was removed and stirring was continued for 1 h. The reaction mixture was partitioned between EtOAc (100 mL)—H2O (100 mL), the organic layer separated, washed with H2O, dried (MgSO4), filtered and concentrated to give the title compound after SiO2 chromatography (CHCl3:MeOH, 10:1).

후처리

  1. customat 0° C.
  2. customThe ice bath was removed
  3. stirringstirring
  4. customThe reaction mixture was partitioned between EtOAc (100 mL)—H2O (100 mL)
  5. customthe organic layer separated
  6. washwashed with H2O
  7. dry with materialdried (MgSO4)
  8. filtrationfiltered
  9. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ba9941c0c4ea4de9add891c79c61b6a5
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06284755B1

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